Founded in January 1995, ChemQuest is the trading name of the scientific consultancy business operated by Dr. David Livingstone. Dave is a physical organic chemist with over 25 years experience in pharmaceutical research.
Initially we were located in Steeple Morden near Cambridge but in 1999 we moved to the Isle of Wight so as to be near the Centre for Molecular Design (link) and the sea ! Following the move, ChemQuest has a dedicated office with a small network of PC's and a Silicon Graphics workstation. The arrival of broadband in Sandown coupled with a wireless router allows me to work anywhere in the house with full connectivity.
The Island is a lovely place to live with different characters in the Summer and Winter. The summer is busy with holidaymakers who, since they are on holiday, are generally happy and relaxed. The winter is quiet and at all times of the year there is a special "island" atmosphere. Good travel links ensure that the "mainland" isn't too far away, even when the seas are rough !
Life isn't just about work so when I'm not working I like to play golf (badly) at my local course (www.ssgolfclub.co.uk) and also go motor racing with a bunch of friends. We did try racing ourselves in a mighty mini (homepage.ntlworld.com/david.gilbert2/main.htm) where we were known as the Last Gasp Racing Team. Sadly, we are no longer racing but we do enjoy the occasional track day. Click on the Icon for proof that Minis can spin !
Founded in January 1995, ChemQuest is the trading name of the scientific consultancy business operated by Dr. David Livingstone. Dave is a physical organic chemist with over 25 years experience in pharmaceutical research. During this time he has been involved in:
The development and application of mathematical and statistical methods such as QSAR, neural networks, and genetic algorithms.
Development of combined QSAR and computational chemistry methods.
Spread of 'drug design' methods to other applications and industries - the mathematical and statistical techniques employed in drug design are not restricted to pharmaceuticals and can, in principle, be applied to the design of any group of "performance" chemicals such as agrochemicals, flavours, fragrances, dyestuffs and so on. (see references 6, 15-16 of complete papers list accessed via Publications page).
Characterisation of intermolecular interactions including the interaction of compounds with proteins such as serum albumin and the measurement of electron-donor-acceptor interactions (charge transfer) in order to provide a descriptor for drug design.
Measurement of physicochemical properties such as pKa and octanol/water partition coefficients.
Biological testing - the effect of compounds on the oxygen dissociation curve of Human haemoglobin in whole blood, red cells and haemoglobin solutions.
